Journal of Cellular and Molecular Physiology

ISSN: 2574-4046

Impact Factor: 0.638


Page No: 50-86

Sapiens mtDNA circular long-range numerical meta-structures are highly correlated with mtDNA diseases mutations

Article Reviewed By:

Zhi-Dong Zhou(

Margarita A. Sazonova, PhD(


perez, Sapiens mtDNA circular long-range numerical meta-structures are highly correlated with mtDNA diseases mutations(2017)SDRP Journal of Cellular and Molecular Physiology 1(1)p:50-86


Using the circular nature of the 16kbase-pairs human mtDNA genome, we are looking for hypothetical proportions between the C + A and T + G bases. Remarkable proportions are thus discovered, the length of which may be much greater than the length of the genome. We then analyze the impact of evolution on these "numerical resonances" by comparing the referenced mtDNAs of Sapiens, Neanderthal and Denisova. Then, by analyzing 250 characteristic mutations associated with various pathologies, we establish a very strong formal causal correlation between these numerical metastructures and these referenced mutations. To summarize, we should think then research on the following situation: Inputs: 250 cases of mtDNA mutations associated with various human diseases. An operator: The exhaustive search for mtDNA genome "Fibonacci resonances" associated with these mutations. A "binary" output: a common behavior of the mtDNA genome resulting from these 250 mutations disorders.


  1. Perez JC (1991) Chaos DNA and neuro-computers: a golden link. Speculations in Science and Technology 14: 336-346.

  2. Marcer PJ (1992) Order and chaos in DNA ? the Denis Guichard Prizewinner: Jean-Claude Perez. Kybernetes 21: 60-61.

    View Article           
  3. MITOMAP: A human mitochondrial genome database,

    View Article           
  4. Shoffner, John M. et al., Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA Lys mutation, Cell, Volume 61, Issue 6, 931 ? 937 PMid:2112427

  5. Wallace DC; et al. (1999). "Mitochondrial DNA variation in human evolution and disease". Gene. 238: 211?30. doi:10.1016/s0378

  6. Wallace DC. 1987. Maternal genes: Mitochondrial diseases. In Medical and experimental mammalian genetics: A perspective (ed. McKusick VA, Roderick TH, Mori J, Paul MW), pp. 137?190. A.R. Liss, New York.

  7. Wallace DC, Chalkia D. Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease. Cold Spring

  8. Harbor Perspectives in Biology. 2013;5(11):a021220. doi:10.1101/cshperspect.a021220. ,

    View Article           
  9. Irina G. Shabalina et al, Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted

  10. Larsson NG1, Somatic mitochondrial DNA mutations in mammalian aging., Annu Rev Biochem. 2010;79:683-706. doi: PMid:20350166

    View Article      PubMed/NCBI     
  11. Eric A. Schon et al, Human mitochondrial DNA: roles of inherited and somatic mutations, Nature Reviews Genetics 13, 878-890 (December 2012) | doi:10.1038/nrg3275

    View Article           
  12. Richard E. Green et al, A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing, Cell. Author manuscript; available in PMC 2009 Aug 8. Published in final edited form as: Cell. 2008 Aug 8; 134(3): 416?426. PMid:18692465 PMCid:PMC2602844

    View Article      PubMed/NCBI     
  13. Susanna Sawyer et al , Nuclear and mitochondrial DNA sequences from two Denisovan individuals, Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51): 15696?15700., Published online 2015 Nov 16. doi: 10.1073/pnas.1519905112 ,PMCID: PMC4697428 Evolution

    View Article           
  14. M. Krings et al (1997) in "Neandertal DNA sequences and the Origin of Modern Humans", Cell, vol 90, 1-20 (July 11, 1997). 80310-4

    View Article           
  15. M. Krings et al (1999) in "DNA sequence of the mitochondrial hypervariable region II from the Neandertal type specimen", Proc. Natl. Acad. Sci. USA, vol 96, pp. 5581-5585, (May 1999). PMid:10318927 PMCid:PMC21903

    View Article      PubMed/NCBI     
  16. C. Duarte et al (1999) in "The early upper Paleolithic Human Skeleton from the Abrigo do Lugar Velho (Portugal) and Modern Human emergence in Iberia, Proc. Natl. Acad. Sci. USA, vol 96, pp. 7604-7609 (June 22, 1999). PMid:10377462 PMCid:PMC22133

    View Article      PubMed/NCBI     
  17. A. Defleur et al (1999) in "Neanderthal Cannibalism at Moula-Guercy, Ard?che, France", Science, vol 286, 128 (October 10, 1999). PMid:10506562

    View Article      PubMed/NCBI     
  18. Fogleman S, Santana C, Bishop C, Miller A, Capco DG. CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations. American Journal of Stem Cells. 2016;5(2):39-52. PMid:27725916 PMCid:PMC5043096

    View Article      PubMed/NCBI     
  19. D.C Wallace, "Mitochondrial Diseases in man and mouse", SCIENCE 283, 1482-1488 (1999). PMid:10066162

    View Article      PubMed/NCBI     
  20. D.C. Wallace and D.G. Murdock, "Mitochondria and Dystonia: The movement disorder connection?", PNAS vol 96, N? 5, 1817-1819 (1999). PMid:10051550 PMCid:PMC33525

    View Article      PubMed/NCBI     
  21. C.M Koehler et al, "Human deafness dystonia syndrome is a mitochondrial disease", PNAS vol 96, N? 5, 2141-2146 (1999). PMid:10051608 PMCid:PMC26750

    View Article      PubMed/NCBI     
  22. Anderson et al, "Sequence and organization of the human mitochondrial genome", NATURE, 290, 457-465 (1981). PMid:7219534

    View Article      PubMed/NCBI     
  23. Ratner, Mark. "Photochemistry: Electronic motion in DNA." Nature 397.6719 (1999): 480-481. 23 ? J.C Perez, De nouvelles voies vers l'intelligence artificielle: pluri-disciplinarite: auto-organisation: r?seaux neuronaux , Masson Paris, 1988.

  24. JC Perez, La r?volution des ordinateurs neuronaux, Herm?s Paris, 1990.

  25. FRACTAL CHAOS a new neural network holographic model JC Perez, JM Bertille, in Neural Networks 1, 121 90160-8

    View Article           
  26. Perez JC (1990) Digital holograms computers, concepts and applications in Neural Networks / Les Reseaux de Neurones: Biological Computers or Electronic Brains / Ordinateurs Biologiques Ou Cerveaux Eletroniques. Les Entretiens de Lyon. Proceedings of the International Conference "Les Entretiens de Lyon" on Neural Networks. Ec... (Paperback), Published December 27th 1990 by Springer, Editors Ren? Moreau and Guy Aubert, ISBN 2-287-00051-8.

  27. Integers neural network systems (INNS) using resonance properties of a Fibonacci's chaoticgolden neuron' JC Perez, Neural Networks, 1990., 1990 IJCNN International Joint Conference on, 859-865

  28. Pellionisz AJ, Graham R, Pellionisz PA , Perez JC (2012) Recursive Genome Function of the Cerebellum: Geometric Unification of Neuroscience and Genomics. In: Manto M, DL, et al. (Eds) Handbook of the Cerebellum and Cerebellar Disorders. 1st (Edn), Springer, USA.

  29. Dokukin ME, Guz NV, Woodworth CD, Sokolov I (2015) Emergence of fractal geometry on the surface of human cervical epithelial cells during progression towards cancer. New J Phys 17

    View Article           
  30. Petoukhov S (2011) Mathematics of Bioinformatics: Theory, Methods and Applications. 1st (Edn), John Wiley & Sons, USA.

  31. R. Coldea, D. A. Tennant, E. M. Wheeler, E. Wawrzynska, D. Prabhakaran, M. Telling, K. Habicht, P. Smeibidl, K. Kiefer. Quantum

    View Article           
  32. Friedman R, Cross M (2013) The Golden Ratio & Fibonacci Sequence: Golden Keys to Your Genius, Health, Wealth & Excellence. 1st (Edn), Hoshin Media, USA.

  33. Persaud, Dharam and O'Leary, James P., "Fibonacci Series, Golden Proportions, and the Human Biology" (2015). HWCOM Faculty Publications. Paper 27.

    View Article           
  34. Hengwu Li, Daming Zhu, Caiming Zhang, Huijian Han, Keith A Crandall (2014) Characteristics and Prediction of RNA structure. BioMed Research International 8.

    View Article           
  35. Vaezi A, Barkeshli M (2014) "Fibonacci Anyons From Abelian Bilayer Quantum Hall States." Physical Review Letters 113.

    View Article           
  36. S.A. Olsen, Riding the Numbers: Ratios & Resonant States of Consciousness, Sociology and Anthropology 5(1): 72-75, 2017 DOI: 10.13189/sa.2017.050108 , /download/20161230/SA8-19608211.pdf

    View Article           
  37. Perez JC (1997) L'adn D?crypt?, Resurgence publisher Liege, Belgium.

  38. Perez JC (2009) Codex Biogenesis. Resurgence, Liege Belgium.

  39. Perez J (2015) Deciphering Hidden DNA Meta-Codes -The Great Unification & Master Code of Biology. J Glycomics Lipidomics

    View Article           
  40. Perez JC (2011) Decoding Non-Coding DNA Codes: Human Genome Meta-Chromosomes Architecture. BIT Life Sciences' 3rd Annual World Vaccine Congress, Beijing, China.

  41. Perez JC (2010) Codon Populations in Single-Stranded Whole Human Genome DNA Are Fractal and Fine-Tuned by the Golden Ratio 1.618. Interdisciplinary Sciences: Computational Life Sciences 2: 1-13.

  42. Perez JC (2013) The "3 Genomic Numbers" Discovery: How Our Genome Single-Stranded DNA Sequence Is "Self Designed" as a Numerical Whole. Applied Mathematics 4: 37-53. 44- Perez J.C. , 41 - ? DUF1220 Homo sapiens fractal periods architectures breakthrough ? , to be published 2017.

  43. Perez J.C. , "The Human Genome Optimum : a numerical universal law controling all LOH chromosomal deletions involved in human cancers ", to be published 2017. 46 ? Perez J.C., "Humans and Primates Chromosomes4 Fractal CODES: periodic stationnary waveforms charaterizing and differenciating Neanderthal and Sapiens whole chromosomes DNA sequences", to be published 2017.

  44. Perez J.C., "Global and long range fractal differences between sapiens and neanderthal genomes", to be published 2017.

  45. Rachel Fleaux, "La Musique des genes", in SCIENCES ? AVENIR french magazine, April 1995.

  46. Diego L. Rapoport (2016) Klein Bottle Logophysics, Self Reference, Heterarchies, Genomic Topologies, Harmonics and Evolution. Part III. The Klein Bottle Logic of Genomics and its Dynamics, Quantum Information, Complexity and Palindromic Repeats in Evolution. Quantum Biosystems. 7(1) 107-174.

  47. TOMASETTI C. et al, Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

  48. Marshall P (2011) Evolution 2.0. Benbella Books, USA. 53 - Montagnier L, A?ssa J, Ferris S, Montagnier JL, Lavall?e C (2009) Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA Sequences. Interdiscip Sci Comput Life Sci 1: 81-90.

  49. Boeyens_Levendis-Number_Theory_and_the_Periodicity_of_Matter (1)

  50. Lieberman-Aiden et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science, 2009; DOI: 10.1126/science.1181369

    View Article           
  51. Jun Wu et al, In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration, Nature (16 November 2016) | doi:10.1038/nature20565 57 - Roman V Yampolskiy, On the origin of synthetic life: attribution of output to a particular algorithm,

    View Article           
  52. Elon Musk's New Startup Wants to Merge Human Brains With Computers, FORTUNE, Mar 27, 2017,

  53. Chargaff rules definition, 60 - Smith DR. The past, present and future of mitochondrial genomics: have we sequenced enough mtDNAs? Briefings in Functional Genomics. 2016;15(1):47-54. doi:10.1093/bfgp/elv027.

    View Article           
  54. Young Seok Ju et al., Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells, Genome

  55. Research, Volume 25, Issue 6, June 2015, doi: 10.1101/gr.190470.115 Genome Res. 2015. ? 2015 Ju et al.; Published by Cold Spring Harbor Laboratory Press ,

    View Article           

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