Srojidinova NZ, Khamidullaeva GA, Tursunova NB, Kurbanova DR,Shermatov ShE , Abdurakhmonov IY
Aleksandr Nagay, ESSENTIAL HYPERTENSION AND GENETIC POOL IN UZBEK POPULATION(2017)SDRP Journal of Cellular and Molecular Physiology 2(1)
Background and objectives: The aim of our study was to determine the features of the distribution of genes associated with hypertension. In this paper we have described the 13 polymorphic loci distinctive susceptibility to hypertension. There are 12 polymorphisms of genes in nuclear DNA and a pool of mitochondrial DNA in D-loop region (HVR1).
Materials and methods: All samples were extracted from human whole blood collected in EDTA or sodium citrate eppendorf tubes. The study included 100 healthy volunteers and 312 patients with I-II grade of essential hypertension EH, all of them were Uzbek males in the mean age of 48.3 ± 8.1 years.
Results: We have found that 17% of inheritance of hypertension in Uzbek population the most closely to Asian type. We have also found dominance of European contribution (83%) to the development of hypertension. Heritage of hypertension in Uzbek population has been evaluated as 17% Eastern, 33% Western, 25% Central Europe, 8% for Anatolia and 17% for South East Asia. The functional significance of all 12 genes in hypertensive patients with combination of atherosclerosis and metabolic syndrome is similar for the most part with European type of heritage. However, a distinctive sensitivity to the exchange of sodium in these individuals is due to 17% of the Asian contribution.
Conclusion: Based on these findings, we have assumed that monogenic Western and hybrid Eastern population of Uzbekistan have different ethnic origins of hypertension heritage. This is confirmed by high population density of the west and low population of the east of country. Since the western region was densely populated, respectively, the number of such settlements exceeded the number of conquerors, which eventually led to small genetic effects on hypertension heritage. The functional significance of 12 genes in Uzbek population with a combination of atherosclerosis and metabolic syndrome is similar 83% in most of European heritage type of hypertension. However, a distinctive sensitivity to the exchange of sodium in these individuals is due to 17% of the Asian contribution.